How Victoza® Works

If you have type 2 diabetes, your body may not produce enough insulin. Or your body may not properly respond to the insulin it does make. Insulin is important because it helps the sugar in the food you eat move from your blood into your cells.

GLP-1 is a hormone made in your body that helps lower blood sugar

When you eat, GLP-1 helps the pancreas release the right amount of insulin to move sugar from the blood into the cells. It also helps slow the process of food leaving your stomach. If your body is not making enough GLP-1 or is not using it correctly, you may not be getting enough insulin to help sugar move from the blood into the cells.

Victoza® helps make more insulin available in your body when needed

Victoza® is 97% similar to GLP-1 (7-37).a It helps make more insulin available in your body when needed. It may also lower your blood sugar levels at the right time with a low rate of hypoglycemia (low blood sugar). Your risk for getting low blood sugar is higher if you take Victoza® with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin. The dose of your sulfonylurea or insulin may need to be lowered while you use Victoza®.

aGLP-1 (7-37) represents <20% of the circulating GLP-1 that is produced by your body.

Victoza® helps beta cells work the way they should

GLP-1 tells important cells in your pancreas, called beta cells, to make insulin when your blood sugar is high. This is important because, over time, beta cells stop working in people with type 2 diabetes. In fact, by the time most people learn they have diabetes, about 80% of their beta-cell function has been lost.

Victoza® is not insulin

Victoza® is not insulin. But it can be taken with long-acting insulin. When using Victoza® with insulin, take them as separate injections. You may give both injections in the same body area (for example, your stomach area), but you should not give the injections right next to each other. Never mix insulin and Victoza® together.

Victoza® may also be taken alone or in combination with one or more common oral type 2 diabetes medicines. These include biguanides (such as metformin), sulfonylureas (SUs), and thiazolidinediones (TZDs).

While not a weight-loss product, Victoza® may help you lose some weight

Medical studies showed that most people taking Victoza® lost some weight. The American Diabetes Association recommends weight loss as an important goal for overweight people with type 2 diabetes.

Save on Victoza®. See how you may be able to save money on your Victoza® prescription.

Indications and Usage

Victoza® (liraglutide [rDNA origin] injection) is an injectable prescription medicine that may improve blood sugar (glucose) in adults with type 2 diabetes when used along with diet and exercise.

Victoza® is not recommended as the first medication to treat diabetes. Victoza® has not been studied in patients with history of inflammation of the pancreas (pancreatitis). Victoza® is not a substitute for insulin and has not been studied in combination with prandial (mealtime) insulin. Victoza® is not for people with type 1 diabetes or people with diabetic ketoacidosis. It is not known if Victoza® is safe and effective in children. Victoza® is not recommended for use in children.

Important Safety Information

In animal studies, Victoza® caused thyroid tumors—including thyroid cancer—in some rats and mice. It is not known whether Victoza® causes thyroid tumors or a type of thyroid cancer called medullary thyroid cancer (MTC) in people, which may be fatal if not detected and treated early. Do not use Victoza® if you or any of your family members have a history of MTC or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). While taking Victoza®, tell your doctor if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer.

Do not use Victoza® if you are allergic to liraglutide or any of the ingredients in Victoza®. Serious allergic reactions can happen with Victoza®. If symptoms of serious allergic reactions occur, stop taking Victoza® and seek medical attention. Pancreatitis may be severe and lead to death. Before taking Victoza®, tell your doctor if you have had pancreatitis, gallstones, a history of alcoholism, or high blood triglyceride levels since these medical conditions make you more likely to get pancreatitis.

Stop taking Victoza® and call your doctor right away if you have pain in your stomach area that is severe and will not go away, occurs with or without vomiting, or is felt going from your stomach area through to your back. These may be symptoms of pancreatitis.

Before using Victoza®, tell your doctor about all the medicines you take, especially sulfonylurea medicines or insulin, as taking them with Victoza® may affect how each medicine works. If you use Victoza® with insulin, you may give both injections in the same body area (for example, your stomach area), but not right next to each other.

Also tell your doctor if you have severe stomach problems such as slowed emptying of your stomach (gastroparesis) or problems with digesting food; have or have had kidney or liver problems; have any other medical conditions; or are pregnant or plan to become pregnant. Tell your doctor if you are breastfeeding or plan to breastfeed. It is unknown if Victoza® will harm your unborn baby or if Victoza® passes into your breast milk.

Your risk for getting hypoglycemia, or low blood sugar, is higher if you take Victoza® with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin. The dose of your sulfonylurea medicine or insulin may need to be lowered while taking Victoza®.

Victoza® may cause nausea, vomiting, or diarrhea leading to dehydration, which may cause kidney failure. This can happen in people who have never had kidney problems before. Drinking plenty of fluids may reduce your chance of dehydration.

The most common side effects with Victoza® include headache, nausea, and diarrhea. Nausea is most common when first starting Victoza®, but decreases over time in most people. Immune system related reactions, including hives, were more common in people treated with Victoza® compared to people treated with other diabetes drugs in medical studies.

Please click here for Prescribing Information and Medication Guide .

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